Evaluation of selected-ion storage ion-trap mass spectrometry for detecting urinary anabolic agents

Evaluation of selected-ion storage ion-trap mass spectrometry for detecting urinary anabolic agents.

Limits of detection are important issues for GC/MS screening for anabolic agents and for confirmation of various drugs of abuse. We compared a quadrupole ion trap (QIT) operated in two different selected-ion storage modes and a quadrupole mass filter (QMF) operated in the selected-ion monitoring mode. Results with the model compound tetrachlorobenzene indicate that, for simultaneous monitoring ...

Quadrupole ion trap mass spectrometry.

A number of other features of ITMS systems that will enhance their ability to analyze biological macromolecules are worth mentioning. As has already been demonstrated for ESI/quadrupole, ESI/magnetic sector, and ESI/FTICR systems, the capability of inducing fragmentation of the ESI-generated multiply charged ions of biological macromolecules in the capillary/skimmer region of the ESI source and...

Selected Tandem Mass Spectrometry Ion

1 Selected tandem mass spectrometry (MS/MS) ion monitoring (SMIM) is the most 2 suitable scanning mode to detect known peptides in complex samples when an ion-trap 3 mass spectrometer is the instrument used for the analysis. In this mode, the MS detector 4 is programmed to perform continuous MS/MS scans on one or more selected 5 precursors, either during a selected time interval, or along the w...

Using AP-MALDI Ion Trap Mass Spectrometry

Atmospheric pressure MALDI/ion trap mass spectrometry.

A new sample ionization technique, atmospheric pressure matrix-assisted laser desorption/ionization (AP MALDI), was coupled with a commercial ion trap mass spectrometer. This configuration enables the application-specific selection of external atmospheric ionization sources: the electrospray/APCI (commercially available) and AP MALDI (built in-house), which can be readily interchanged within mi...